Precision Medicine for Frontotemporal Dementia

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چکیده

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Precision medicine of frontotemporal dementia: from genotype to phenotype.

Frontotemporal dementia (FTD) is the second most common neurodegenerative  cause of early-onset dementia. FTD has an important genetic component contributing to its pathogenic mechanisms. Currently, extensive research on neuroimaging biomarkers and neurochemical biomarkers in FTD is being conducted to address the clinical need for a sensitive and specific diagnostic marker. Here, we review the ...

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Assessment of Aphasia in Iranian Patients Suffering From Frontotemporal Dementia

Objective Frontotemporal dementia (FTD) is an uncommon type of dementia. The hallmark feature of FTD is the presentation with aphasia, or behavioral changes which are varies in different subtypes of the disease. We propose a quantitative aphasia test as an additive diagnostic tool for differentiation of FTD subtypes. Method: The study was performed on 20 patients, who were referred to dementia...

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Frontotemporal dementia

OBJECTIVE Describe the relationships between the clinical, neuropsychological, and imaging findings from a group of patients diagnosed with frontotemporal dementia (FTD). METHODS The clinical histories, cognitive tests, and structural and perfusion brain images of 21 patients of the Psychiatric Hospital Universitario del Valle, Cali, Colombia, were reviewed. RESULTS The average age was 59.8...

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Frontotemporal dementia

Keywords Disease name / synonyms Included diseases Definition, clinical description and diagnostic criteria Differential diagnosis Diagnostic methods Epidemiology Etiology Genetic counseling Management including treatment Unresolved questions References Abstract Frontotemporal dementia (FTD) is the prototypical behavioural disorder arising from frontotemporal cerebral atrophy. Depending on the ...

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ژورنال

عنوان ژورنال: Frontiers in Psychiatry

سال: 2019

ISSN: 1664-0640

DOI: 10.3389/fpsyt.2019.00075